BIG FAT RED CELLS
B12 malabsorption
Inherited
Gastrointestinal disease
Folic acid deficiency
Alcoholism
Thiamine responsive
Reticulocytes (mis-counted as large RBCs)
Endocrine (hypothyroid)
Dietary
Chemotherapeutic drugs
Erythro leukemia
Liver disease
Lesch-Nyhan syndrome
Splenectomy